Antimicrobial susceptibility testing (AST)


AST background

Molecular-based, PCR-less identification of species-specific phenotypic markers of resistance and susceptibility, as they are clinically relevant end products of many genetic pathways 

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Directly from patient whole blood samples, no need to wait for positive blood cultures. 

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Diagnostic tests help guide appropriate use of antibiotics and decrease inappropriate antibiotic use by lessening the need for clinicians to treat patients empirically. 

The only antimicrobial susceptibility testing that can directly test on patient whole blood samples 

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120 MINUTES FOR A DIAGNOSTIC USED IN A PHYSICIAN’S OFFICE OR THE ED FOR OUTPATIENT BLOODSTREAM INFECTION RESISTANCE PROFILING  

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240 MINUTES FOR A DIAGNOSTIC USED FOR INPATIENT HOSPITAL ACQUIRED INFECTION (HAI) RESISTANCE PROFILING 

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Site-specific antibiogram 

antibiogram

 Antimicrobial Stewardship program

AST blood
AST dna

Patient whole blood sample 

 Pathogen identification

Direct resistance profiling

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Categorization 

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Resistance profiling 

DNA1
DNA1

Viral 

 Gram –

 Fungal

 Gram +

 Phenotypic culture

 MIC or resistance reporting

 MIC or resistance reporting

Amplicillin Culture 

 Cefazolin culture

 Gentamicin culture

 Tobramycin culture

Comprehensive phenotypic culture

AST data
medicine

 Molecular-based phenotypic resistance

• Phenotypic testing

• Evidence-based 

• 60-120 minutes 

• MIC reporting 

• Multiplexed 

 Multi-drug resistance 

 Liao lab at Stanford University

clinical testing sites

Multi-site Clinical feasibility testing